RG7112
CAS No. : 939981-39-2
(Synonyms: RO5045337)
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $360 | In-stock |
| 50mg | $540 | In-stock |
| 100mg | $800 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-10959 |
| M.Wt: | 727.78 |
| Formula: | C38H48Cl2N4O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
RG7112 is a potent, selective, orally active and blood-brain barrier crossed MDM2-p53 inhibitor, with an IC50 of 18 nM and a KD of 11 nM for binding to MDM2[1].
IC50 & Target:Kd: 11 nM (MDM2)[1]
In Vitro:RG7112 (0-5 μM) stabilizes wild-type p53 and induces p53 signaling in cancer cells. RG7112 effectively activates p53 functions in cancer cells[1][2].
In Vivo:RG7112 (25-200 mg/kg, single oral dose) activates p53 pathway and induces apoptosis in tumor cells in vivo[2].
RG7112 (100 mg/kg, gavage once per day, 5 days/week for 3 weeks ) reduces tumor growth rate and increases survival in GBM models[3].
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