Mometasone furoate

CAS No. : 83919-23-7

(Synonyms: Sch32088)

Price and Availability of CAS No. : 83919-23-7
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50mg $60 In-stock
100mg $96 In-stock
200mg $156 In-stock
500mg $228 In-stock
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Cat. No. : HY-13693
M.Wt: 521.43
Formula: C27H30Cl2O6
Purity: >98 %
Solubility: DMSO : 50 mg/mL (95.89 mM; Need ultrasonic)
Introduction of 83919-23-7 :

Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity. Mometasone furoate acts as a corticosteroid agent and used for topical applications in chronic skin eczema and airway inflammation management of asthma in vivo[1] IC50 & Target: IC50: Glucocorticoid Receptor In Vitro: Mometasone furoate binds to a glucocorticoid receptor causes conformational changes in the receptor, separation from chaperones, and the receptor moves to the nucleus[1].
Mometasone furoate (0.1-10 μM; 2h before LPS stimulation) strongly inhibits LPS-stimulated nitrite production in a concentration-dependent manner in J774 macrophages, The IC50 value is 0.00024 μM for Mometasone furoate in J774 cells[1].
Mometasone furoate (0.1-10 μM; 2h before LPS stimulation) is more potent than DEX, it significantly inhibits iNOS expression at a 0.01 µM concentration whereas Dex became active at 0.1 µM. Additionally, the inhibition of cox-2 protein expression at 0.01 μM is 79% for Mometasone furoate and 39% for Dex[1].

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