NSC348884
CAS No. : 81624-55-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $72 | In-stock |
| 10mg | $127 | In-stock |
| 25mg | $253 | In-stock |
| 50mg | $418 | In-stock |
| 100mg | $605 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-13915 |
| M.Wt: | 636.79 |
| Formula: | C38H40N10 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 34 mg/mL (53.39 mM) |
NSC348884 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell proliferation with IC50s of 1.7-4.0 μM in distinct cancer cell lines. NSC348884 can be used for the research of cancer[1]. IC50 & Target: IC50: 4 μM (LNCaP cells), 1.7 μM (Granta cells)[1] In Vitro: NSC348884 (0-6 μM; 24 h) binds with NPM and disrupts NPM oligomer formation[1]. NSC348884 (0.01-100 μM; 4 d) shows cytotoxicity to cancer cells[1]. NSC348884 (1 μM; 4 d) shows cytotoxicity to mantle cell lymphoma with 0.1 nM doxorubicin[1]. NSC348884 (1-5 μM; 24 h) induces cell apoptosis[1]. NSC348884 (0-5 μM; 0-24 h) upregulates the concentration of p53[1]. In Vivo: NSC348884 (50 μg; i.p. once) reduces tumor growth[2].
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