RGX-104


CAS No. : 610318-54-2

610318-54-2
Price and Availability of CAS No. : 610318-54-2
Size Price Stock
2mg $110 In-stock
5mg $170 In-stock
10mg $270 In-stock
50mg $840 In-stock
100mg $1250 In-stock
200 mg Get quote
500 mg Get quote
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Cat. No. : HY-111498A
M.Wt: 596.08
Formula: C34H33ClF3NO3
Purity: >98 %
Solubility: DMSO : 100 mg/mL (167.76 mM; Need ultrasonic)
Introduction of 610318-54-2 :

RGX-104 is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene. IC50 & Target: LXR[1] In Vivo: Oral administration of RGX-104 (100 mg/kg, daily) to animals bearing palpable tumors significantly suppresses the growth of multiple cancer types. Co-administration of RGX-104 with anti-PD-1 is superior to administration of either RGX-104 or anti-PD-1 alone. Importantly, co-administration of RGX-104 with anti-PD-1 therapy is well tolerated by mice, with no overt signs of toxicity[1].

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