Hesperidin
CAS No. : 520-26-3
(Synonyms: Hesperetin 7-rutinoside)
| Size | Price | Stock |
|---|---|---|
| 5mg | $42 | In-stock |
| 10mg | $66 | In-stock |
| 25mg | $95 | In-stock |
| 50mg | $119 | In-stock |
| 100mg | $158 | In-stock |
| 200mg | $211 | In-stock |
| 500mg | $251 | In-stock |
| 1g | $383 | In-stock |
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| Cat. No. : | HY-15337 |
| M.Wt: | 610.56 |
| Formula: | C28H34O15 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Hesperidin (Hesperetin 7-rutinoside), a flavanone glycoside, is isolated from citrus fruits. Hesperidin has numerous biological properties, such as decreasing inflammatory mediators and exerting significant antioxidant effects. Hesperidin also exhibits antitumor and antiallergic activities[1][2].
In Vitro: Hesperidin (5-200 µM; 24-72 h) induces potent cytotoxic effects in human osteosarcoma MG-63 cells[1].
Hesperidin (5-150 µM; 48 h) induces early and late apoptosis in MG-63 cells[1].
Hesperidin (10-30 µM) inhibits the activity of COX-2 and iNOS in a dose dependent manner in RAW 264.7 cells activated with LPS[2].
Hesperidin (0.1 μg/mL; 2 h) decreases the formation of MDA and intracellular ROS, including chondrocyte apoptosis[3].
In Vivo: Hesperidin (5-80 mg/kg; 2 weeks) significantly suppresses MG-63 tumor growth in mice[1].
Hesperidin (200 mg/kg; once daily for 28 d) markedly attenuates cartilage destruction and reduces IL-1β and TNF-α levels in a surgically-induced osteoarthritis (OA) rats[3].
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