Nabumetone


CAS No. : 42924-53-8

(Synonyms: BRL14777)

42924-53-8
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Cat. No. : HY-B0559
M.Wt: 228.29
Formula: C15H16O2
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL (438.04 mM); H2O : < 0.1 mg/mL (insoluble)
Introduction of 42924-53-8 :

Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the prodrug of the active metabolite 6MNA. IC50 & Target: COX-2[1] In Vitro: Nabumetone is a potent and selective COX-2 inhibitor. Nabumetone (50 μmol-2 mmol) dose-dependently inhibits the proliferation of K-562 and Meg-01 cells, but shows no obvious apoptotic effect. Nabumetone potentiates the apoptotic effect of ADR in the K-562 cell line. Moreover, Nabumetone reduces Bcl-2 expression[1]. In Vivo: Nabumetone (79 mg/kg, p.o.) inhibits paw oedema and paw exudate PGE2 in rats. Nabumetone does not induce gastric damage and causes only 57% inhibition of gastric mucosal 6-keto-PGF production in rats[2]. Nabumetone (25, 50, 100 mg/kg, i.p.) dose-dependently inhibits the increase of DDC-induced mucus secretion and stimulates stress-induced mucus secretion in rats. Nabumetone (25 mg/kg, i.p.) significantly suppresses stress-induced ulcer index in rats[3].

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