Betamethasone


CAS No. : 378-44-9

378-44-9
Price and Availability of CAS No. : 378-44-9
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100mg $66 In-stock
500mg $264 In-stock
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Cat. No. : HY-13570
M.Wt: 392.46
Formula: C22H29FO5
Purity: >98 %
Solubility: DMSO : ≥ 50 mg/mL (127.40 mM)
Introduction of 378-44-9 :

Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4]. In Vitro: Betamethasone (0.1-1 μM; 12 h) induces gene expression in L929 cells[4].
Betamethasone (0.1-1 μM; 48 h) induces CEM C7 T-cells apoptosis[4]. In Vivo: Betamethasone (0.48 mg; i.v.gtt for 48 h) decreases the hypercapnia-induced increase in CBF due to decreased cerebral vasodilatation[1]. Betamethasone (0.05 ml (1 mg/L); topical injection) ameliorates spinal nerve transection induced mechanical allodynia and thermal hyperalgesia, and reduces the activation of NF-κB and elevation of TNFα and IL-1β, and induces the expression of IL-10 in the rats brain[2].

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