CAS No. : 35212-22-7

Price and Availability of CAS No. : 35212-22-7
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Cat. No. : HY-N0094
M.Wt: 280.32
Formula: C18H16O3
Purity: >98 %
Solubility: DMSO : 33.33 mg/mL (118.90 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble)
Introduction of 35212-22-7 :

Ipriflavone is a synthetic isoflavone derivative used to suppress bone resorption. In Vitro: Ipriflavone inhibits the proliferation and DNA synthesis of MDA-231 cells and blocks the ligand-induced phosphorylation of Tyr(845) of the EGFR. Ipriflavone does not promote apoptosis of MDA-231 cells[1]. Ipriflavone also promotes the deposition of calcium and the formation of mineralized nodules by newborn rat calvarial osteoblast-like cells as well as the activity of alkaline phosphatase[2]. In Vivo: Daily oral administration of ipriflavone at 12 mg/mouse significantly inhibits the development of new osteolytic bone metastases and the progression of established osteolytic lesions, prolonging the life of tumor-bearing mice. Ipriflavone reduces the number of osteoclasts at the bone-cancer interface with no severe adverse effects on the host[1]. 1-month treatment with ipriflavone increases bone density and improves the biomechanical properties of adult rat male bones without altering mineral composition[3]

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