CCF642
CAS No. : 346640-08-2
| Size | Price | Stock |
|---|---|---|
| 2mg | $50 | In-stock |
| 5mg | $75 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $230 | In-stock |
| 50mg | $380 | In-stock |
| 100mg | $580 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-100430 |
| M.Wt: | 378.45 |
| Formula: | C15H10N2O4S3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 30 mg/mL |
CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC50 of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity[1].
IC50 & Target: IC50: 2.9 μM (PDI)[1]
In Vitro: CCF642 (3 μM; 0.5-6 hours) increases PERK dimerization by phosphorylation and IRE1-α oligomerization within 30 minutes in KMS-12-PE confirming accumulation of misfolded ER proteins[1].
CCF642, a bone marrow-sparing compound, exhibits a submicromolar IC50 in 10 of 10 multiple myeloma cell lines (MM1.S, MM1.R, KMS-12-PE, KMS-12-BM, NCI-H929, U266, RPMI 8226, JJN-3, HRMM.09-luc, 5TGM1-luc)[1].
In Vivo: CCF642 (10 mg/kg; i.p.; three times a week; for 24 days) significantly prolongs life of 5TGM1-luc-bearing mice and suppresses 5TGM1-luc growth as determined by life imaging[1].
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