KRIBB11
CAS No. : 342639-96-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $96 | In-stock |
| 25mg | $216 | In-stock |
| 50mg | $360 | In-stock |
| 100mg | $648 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100872 |
| M.Wt: | 284.27 |
| Formula: | C13H12N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 150 mg/mL (ultrasonic) |
KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 μM. IC50 & Target: IC50: 1.2 μM (HSF1)[1] In Vitro: KRIBB11 blocks the induction of HSF1 downstream target proteins such as HSP27 and HSP70. KRIBB11 induces growth arrest and apoptosis of HCT-116 cells. KRIBB11 inhibits HSF1-dependent recruitment of p-TEFb (positive transcription elongation factor b) to the hsp70 promoter[1]. PARP and caspase-3 cleavage is increased in cells treated with KRIBB11. Incubating RKO with KRIBB11, shows a toxic threshold of about 10 µM, and an IC50 of 20-30 µM[2]. In Vivo: KRIBB11 (50 mg/kg, i.p.) results in a 47.4% inhibition of tumor growth in nude mice, without body weight loss[1].
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