Chembridge-5861528
CAS No. : 332117-28-9
(Synonyms: TCS 5861528)
| Size | Price | Stock |
|---|---|---|
| 5mg | $79 | In-stock |
| 10mg | $132 | In-stock |
| 50mg | $528 | In-stock |
| 100mg | $924 | In-stock |
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| Cat. No. : | HY-15065 |
| M.Wt: | 369.42 |
| Formula: | C19H23N5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 120 mg/mL (324.83 mM; Need ultrasonic) |
Chembridge-5861528 (TCS 5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively. Chembridge-5861528 shows antihypersensitivity activities[1].
In Vitro: Chembridge-5861528 (TCS 5861528) shows no TRPA1 or TRPV1 channel agonism and no TRPV1 channel antagonism up to a dose of 100 μM[1].
In Vivo: Chembridge-5861528 (TCS 5861528) (30 mg/kg; i.p.; twice daily for a week) significantly attenuates development of mechanical hypersensitivity in Streptozocin (HY-13753)-induced diabetes mellitus rat model[1].
Chembridge-5861528 (3 and 10 μg/rat; i.t.; once) attenuates Capsaicin (HY-10448)-induced blood flow increase in a dose-related fashion[2].
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