CQ627
CAS No. : 3093767-34-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $1020 | In-stock |
| 10mg | $1700 | In-stock |
| 25mg | $3060 | In-stock |
| 50mg | $4284 | In-stock |
| 100mg | $5569 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-170574 |
| M.Wt: | 697.64 |
| Formula: | C36H27F4N7O4 |
| Purity: | >98 % |
| Solubility: |
CQ627 is a molecular glue targeting the degradation of RIOK2. It effectively induces the degradation of RIOK2 in the MOLT4 leukemia cell line via the ubiquitin-proteasome system (UPS) by recruiting the E3 ubiquitin ligase RNF126, with a DC50 value of 410 nM. CQ627 dose-dependently induces apoptosis in MOLT4 leukemia cells, blocks their cell cycle in the G2/M phase, and exhibits antiproliferative activities in various cancer cell lines. CQ627 also demonstrates in vivo anticancer activity in a MOLT4 xenograft mouse model[1].
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