KL201
CAS No. : 302939-48-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $190 | In-stock |
| 10mg | $305 | In-stock |
| 25mg | $610 | In-stock |
| 50mg | $900 | In-stock |
| 100mg | $1250 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-134194 |
| M.Wt: | 388.28 |
| Formula: | C17H14BrN3OS |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 has no stabilizing effect on CRY2. KL201 lengthens the period of circadian rhythms in cells and tissues[1].
In Vitro: KL201 causes dose-dependent lengthening of circadian period in Bmal1-dLuc reporter cells, and in cells with another circadian reporter Per2-dLuc. KL201 suppresses the intensity of Per2-dLuc reporter much more than that of Bmal1-dLuc, without affecting cellular viability[1].
KL201 binds to CRY1 in overlap with FBXL3, a subunit of ubiquitin ligase complex, and the effect of KL201 is blunted by knockdown of FBXL3[1].
KL201 lengthened circadian period and suppressed the intensity of Per2::Luc knockin reporter in mouse lung primary explants[1].
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