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|---|---|---|
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| Cat. No. : | HY-161784 |
| M.Wt: | 514.61 |
| Formula: | C28H36F2N4O3 |
| Purity: | >98 % |
| Solubility: |
GABAA receptor modulator-5 (Compound S28) is a modulator for (γ-aminobutyric acid)A receptor (GABAA receptor), with EC50 of 56 nM and 10 nM, for α1β2γ2 and α4β3δ subtype. GABAA receptor modulator-5 exhibits good pharmacokinetic characteristics in rats. GABAA receptor modulator-5 is slightly toxic toxicity in rats with a loss of rollover reflex (LORR) threshold dose of 23.3 μmol/kg, and exhibits potential ameliorating the postpartum depression[1]. IC50 & Target:EC50: 56 nM (GABAA receptor α1β2γ2); 10 nM (GABAA receptor α4β3δ)
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