PARG-IN-4
CAS No. : 2988890-20-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $260 | In-stock |
| 5mg | $650 | In-stock |
| 10mg | $1050 | In-stock |
| 25mg | $2100 | In-stock |
| 50mg | $3400 | In-stock |
| 100mg | $5450 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-156881 |
| M.Wt: | 497.59 |
| Formula: | C20H25F2N7O2S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic;warming;heat to 80°C) |
PARG-IN-4 (Formula (A)) is an orally available PARG inhibitor (EC50=1.9 nM) with cell membrane permeability. PARG-IN-4 can effectively inhibit tumor growth in mouse models. PARG-IN-4 can be used in cancer research[1]. IC50 & Target:EC50: 1.9 nM (Poly(ADP-ribose) Glycohydrolase (PARG)) In Vitro:PARG-IN-4 (Formula (A)) affects the cell viability of SNU601 and RMUGS cells with EC50 of 11 nM and 4.2 nM, respectively; and exhibits antiproliferative activity against ovarian and breast cancer cells[1]. In Vivo:PARG-IN-4 (Formula (A)) (100 mg/kg; po; QD; 45 d) induces tumor regression in a patient-derived HBCx-34 xenograft mouse model[1].
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