(Rac)-PROTAC PARP/EGFR ligand 1


CAS No. : 2935073-36-0

2935073-36-0
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Cat. No. : HY-141486
M.Wt: 1020.52
Formula: C53H56ClF2N9O8
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 2935073-36-0 :

(Rac)-PROTAC PARP/EGFR ligand 1 incorporates a ligand for PARP and EGFR , and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). (Rac)-PROTAC PARP/EGFR ligand 1 can be used in the synthesis of DP-C-4, which is CRBN-based dual PROTAC for simultaneous degradation of EGFR and PARP[1]. (Rac)-PROTAC PARP/EGFR ligand 1 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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