PLX-3618
CAS No. : 2851986-76-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $430 | In-stock |
| 10mg | $700 | In-stock |
| 25mg | $1500 | In-stock |
| 50mg | $2400 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-161779 |
| M.Wt: | 601.68 |
| Formula: | C32H27N9O2S |
| Purity: | >98 % |
| Solubility: |
PLX-3618 is a molecular glue, that degrades BRD4 with DC50 of 12.2 nM. PLX-3618 promotes polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting of the E3 ligase substrate receptor, DCAF11. PLX-3618 inhibits the proliferation of various cancer cells, induces apoptosis in AML cells. PLX-3618 exhibits antitumor activity against AML in mouse models[1].
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