BSJ-04-132
CAS No. : 2349356-39-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $350 | In-stock |
| 10mg | $560 | In-stock |
| 25mg | $1120 | In-stock |
| 50mg | $1790 | In-stock |
| 100mg | $2860 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-136252 |
| M.Wt: | 819.91 |
| Formula: | C42H49N11O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
BSJ-04-132 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity[1].
In Vitro: BSJ-04-132 (0.1-5 μM; for 4 hours) only resultes in degradation of CDK4 in WT cells, not CDK6 and IKZF1/3[1].
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