NVP-DFV890


CAS No. : 2271394-34-2

(Synonyms: NLRP3 antagonist 2)

2271394-34-2
Price and Availability of CAS No. : 2271394-34-2
Size Price Stock
5mg $415 In-stock
10mg $670 In-stock
25mg $1340 In-stock
50mg $2140 In-stock
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Cat. No. : HY-155876
M.Wt: 420.55
Formula: C19H24N4O3S2
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 2271394-34-2 :

NVP-DFV890 is an orally administered, selective NLRP3 inhibitor. NVP-DFV890 directly binds to NLRP3, blocks maturation of pro-inflammatory cytokines IL-1β and IL-18, and inhibits pyroptotic cell death. NVP-DFV890 acts as an inducer of viral clearance, promoting earlier clearance of SARS-CoV-2. NVP-DFV890 can be used for the research of COVID-19 pneumonia and coronavirus-associated acute respiratory distress syndrome (CARDS)[1]. In Vivo:DFV890 inhibits NLRP3-mediated IL-1β and IL-18 secretion and pyroptotic cell death in mechanistic mouse models of inflammation[1].

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