Almonertinib (hydrochloride)
CAS No. : 2134096-03-8
(Synonyms: HS-10296 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $197 | In-stock |
| 10mg | $290 | In-stock |
| 25mg | $497 | In-stock |
| 50mg | $690 | In-stock |
| 100mg | $970 | In-stock |
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| Cat. No. : | HY-112823B |
| M.Wt: | 562.11 |
| Formula: | C30H36ClN7O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic);H2O : 12.5 mg/mL (ultrasonic;warming;heat to 60°C) |
Almonertinib (HS-10296) hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib hydrochloride shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib hydrochloride is used for the research of the non-small cell lung cancer[1][2]. IC50 & Target: EGFR[1]. In Vitro: Almonertinib (HS-10296) is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC[2]. Additionaly, Almonertinib (HS-10296) could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q[3].
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