HaXS8
CAS No. : 2080306-25-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $260 | In-stock |
| 2mg | $390 | In-stock |
| 5mg | $780 | In-stock |
| 10mg | $1250 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-131015 |
| M.Wt: | 787.20 |
| Formula: | C35H43ClF4N6O8 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
HaXS8 is a dimerizer that can promote a covalent and irreversible intracellular dimerization of HaloTag and SNAP-tagged proteins of interest. HaXS8 does not interfere with PI3K/mTOR signaling[1][2].
In Vitro: HaXS8 promotes intracellular dimerization of Halo-GFP and SNAP-GFP fusion proteins reached >65%, and displays significant intracellular dimerization as low as 50 nM in HeLa cells[1].
HaXS8 (0.5 μM; 40 min) induces a rapid and efficient cross-linking of the membrane anchor and the iSH2 construct, and triggers the activation of the downstream targets PKB/Akt and mTOR in HEK293 cells[1].
HaXS8 (0.5 μM; 40 min) does not upregulate MAPK phosphorylation in HEK293 cells[1].
HaXS8 (0.5 μM; 1 h) does not interfere with PI3K/mTOR signaling in HEK293 cells[1].
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