BTX161
CAS No. : 2052301-24-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $380 | In-stock |
| 10mg | $600 | In-stock |
| 25mg | $1150 | In-stock |
| 50mg | $1800 | In-stock |
| 100mg | $2850 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-120084 |
| M.Wt: | 272.30 |
| Formula: | C15H16N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C) |
BTX161, a Thalidomide analog, is a potent CKIα degrader, and belonging to PROTAC related Ligands for E3 Ligase. BTX161 mediates degradation of CKIα better than Lenalidomide in human AML cells and activates DNA damage response (DDR) and p53, while stabilizing the p53 antagonist MDM2[1].
In Vitro:BTX161 (25 μM; 4 hours; MV4-11 cells) upregulates all the Wnt targets including MYC and does not affect MDM2 mRNA expression[1].
BTX161 (10 μM; 6 hours; MV4-11 cells), on its own, augmentes p53 and MDM2 protein expression, yet in combination with THZ1, and particularly with both THZ1 and CDK9, further augmentes p53 and induces maximal caspase 3 activation[1].
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