TP-008
CAS No. : 1976038-41-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $155 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $477 | In-stock |
| 50mg | $785 | In-stock |
| 100mg | $1290 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-125851 |
| M.Wt: | 411.82 |
| Formula: | C20H15ClFN5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 9.6 mg/mL (ultrasonic;warming) |
TP-008 is a potent, selective and orally active (Activin-Like Kinase 5) ALK5 inhibitor with pIC50 and pEC50 values of 7.6 and 6.63, respectively. TGFβRI-IN-2 can produce observed cardiac toxicity in vivo at high dose[1]. IC50 & Target: IC50: ALK 5[1] In Vitro: TP-008 at 1 μM shows a 31% inhibition of MAP3K2 (MEKK2) with an IC50 value of 2.2?μM[1]. In Vivo: TP-008 (oral administation; 50, 150 and 500 mg/kg; 5 days) induces cardiovascular toxicity characterized by valvular interstitial cell proliferation, neutrophil presence, hemorrhage and fibrin deposition in the heart valves[1].
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