Abeprazan (hydrochloride)
CAS No. : 1902954-87-3
(Synonyms: DWP14012 (hydrochloride); Fexuprazan (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 1mg | $70 | In-stock |
| 5mg | $183 | In-stock |
| 10mg | $255 | In-stock |
| 25mg | $410 | In-stock |
| 50mg | $550 | In-stock |
| 100mg | $710 | In-stock |
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| Cat. No. : | HY-109079A |
| M.Wt: | 446.87 |
| Formula: | C19H18ClF3N2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases[1]. In Vitro: The mechanism of action of Abeprazan hydrochloride is reversibly binding to H+, K+‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation[1]. In Vivo: Abeprazan hydrochloride (DWP14012 hydrochloride) inhibits acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion is equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models[1].
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