Selonsertib


CAS No. : 1448428-04-3

(Synonyms: GS-4997)

1448428-04-3
Price and Availability of CAS No. : 1448428-04-3
Size Price Stock
5mg $92 In-stock
10mg $121 In-stock
50mg $270 In-stock
100mg $490 In-stock
200mg $704 In-stock
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Cat. No. : HY-18938
M.Wt: 445.49
Formula: C24H24FN7O
Purity: >98 %
Solubility: DMSO : ≥ 31 mg/mL (69.59 mM)
Introduction of 1448428-04-3 :

Selonsertib (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. IC50 & Target: pIC50: 8.3±0.07 (ASK1)[1] In Vitro: Selonsertib (GS-4997) is a clinical stage ASK1 inhibitor, which has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis[1]. Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain[2].

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