Selonsertib
CAS No. : 1448428-04-3
(Synonyms: GS-4997)
| Size | Price | Stock |
|---|---|---|
| 5mg | $84 | In-stock |
| 10mg | $110 | In-stock |
| 50mg | $245 | In-stock |
| 100mg | $445 | In-stock |
| 200mg | $640 | In-stock |
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| Cat. No. : | HY-18938 |
| M.Wt: | 445.49 |
| Formula: | C24H24FN7O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 31 mg/mL (69.59 mM) |
Selonsertib (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. IC50 & Target: pIC50: 8.3±0.07 (ASK1)[1] In Vitro: Selonsertib (GS-4997) is a clinical stage ASK1 inhibitor, which has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis[1]. Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain[2].
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