NE 52-QQ57
CAS No. : 1401728-56-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $600 | In-stock |
| 100mg | $900 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101784 |
| M.Wt: | 416.52 |
| Formula: | C24H28N6O |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic;warming;adjust pH to 5 with HCl;heat to 60°C) |
NE 52-QQ57 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 has anti-inflammatory activity[1]. IC50 & Target: IC50: 70 nM (GPR4)[1]. In Vitro: NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation (IC50 26.8 nM in HEK293 cells)[2]. In Vivo: NE 52-QQ57 (Compound 13) shows a significant anti-inflammatory effect in the rat antigen induced arthritis model after oral administration at 30 mg/kg bid for 20 days[1]. NE 52-QQ57 (30 mg/kg bid po for 4 days) also prevents angiogenesis in the mouse chamber model as well as pain as demonstrated in the rat complete Freund’s adjuvant model[1].
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