Ro 41-1049 (hydrochloride)

CAS No. : 127917-66-2

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Cat. No. : HY-100027A
M.Wt: 301.77
Formula: C12H13ClFN3OS
Purity: >98 %
Solubility: DMSO : ≥ 32 mg/mL (106.04 mM); H2O : 25 mg/mL (82.84 mM; Need ultrasonic)
Introduction of 127917-66-2 :

Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (MAO-A). An homogeneous population of high affinity binding sites for [3H]Ro 41-1049 is found in membrane preparations from human frontal cortex and placenta (Kd values of 16.5 and 64.4 nM, respectively)[1]. IC50 & Target: MAO-A[1] In Vivo: Ro 41-1049 (1-50 mg/kg; intraperitoneal injection; for 3 hours; Sprague-Dawley rats) treatment inhibits dopamine metabolite formation and increases dopamine levels in a dose-dependent fashion. Pretreatment with Ro 41-1049 (20 mg/kg) significantly increases dopamine formation following L-dopa administration (100 mg/kg IP) while decreasing formation of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)[2].

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