Ro 41-1049 (hydrochloride)
CAS No. : 127917-66-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $72 | In-stock |
| 10mg | $108 | In-stock |
| 50mg | $288 | In-stock |
| 100mg | $480 | In-stock |
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| Cat. No. : | HY-100027A |
| M.Wt: | 301.77 |
| Formula: | C12H13ClFN3OS |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 32 mg/mL (106.04 mM); H2O : 25 mg/mL (82.84 mM; Need ultrasonic) |
Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (MAO-A). An homogeneous population of high affinity binding sites for [3H]Ro 41-1049 is found in membrane preparations from human frontal cortex and placenta (Kd values of 16.5 and 64.4 nM, respectively)[1]. IC50 & Target: MAO-A[1] In Vivo: Ro 41-1049 (1-50 mg/kg; intraperitoneal injection; for 3 hours; Sprague-Dawley rats) treatment inhibits dopamine metabolite formation and increases dopamine levels in a dose-dependent fashion. Pretreatment with Ro 41-1049 (20 mg/kg) significantly increases dopamine formation following L-dopa administration (100 mg/kg IP) while decreasing formation of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)[2].
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