BCI
CAS No. : 1245792-51-1
(Synonyms: (E)-BCI)
| Size | Price | Stock |
|---|---|---|
| 1mg | $66 | In-stock |
| 5mg | $165 | In-stock |
| 10mg | $275 | In-stock |
| 25mg | $470 | In-stock |
| 50mg | $620 | In-stock |
| 100mg | $805 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-115502 |
| M.Wt: | 317.43 |
| Formula: | C22H23NO |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
BCI ((E)-BCI) is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI can be used in inflammatory disease research[1][2].
In Vitro:BCI (100 ng/mL; 24 h) downregulats the expression of DUSP6 in RAW264.7 macrophage cells[2].
BCI (0-1 nM; 24 h) inhibits the expression of IL-1β and IL-6 in lipopolysaccharide- (LPS-) activated macrophages[2].
BCI (0-4 nM; 24 h) decreases ROS production and activates the Nrf2 Pathway in LPS-activated macrophages[2].
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