sEH inhibitor-1
CAS No. : 1208549-68-1
Price and Availability of
CAS No. : 1208549-68-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $60 | In-stock |
| 5mg | $200 | In-stock |
| 10mg | $320 | In-stock |
| 25mg | $640 | In-stock |
| 50mg | $1050 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-120494 |
| M.Wt: | 371.35 |
| Formula: | C17H20F3N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Introduction of
1208549-68-1
:
a: Tmax, the time of maximum concentration; Cmax, the maximum blood concentration; MRT, the mean residence time; and AUCt, area under the concentration-time curve to terminal time. Additional PK parameters with non-compartmental model are presented in Table S3.
d: The dose with the unit of μmol/kg.
sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively[1].
IC50 & Target: sEH[1]
In Vivo: Pharmacokinetic parameters of sEH inhibitor-1 (TCPU) after oral gavage with a non-compartmental analysis[1].
| Doses (mg/kg) | Cmaxa (nmol/L) | Tmax (h)a | AUCt (uM?h)a | MRT (h)a |
| 0.1 (0.27d) | 270±120 | 5.3±1.2 | 2.2±1.1 | 18.9±6.6 |
| 0.3 (0.81d) | 1680±1170 | 4.7±1.2 | 16.6±8.8 | 16.9±5.4 |
| 1.0 (2.69d) | 2560±95 | 3.2±2.2 | 43.8±5.1 | 24.0±1.8 |
| 3.0 (8.08d) | 5160±265 | 3.9±2.5 | 94.3±8.0 | 32.1±5.6 |
d: The dose with the unit of μmol/kg.
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