IR-783

IR-783 (ADS 780WS) is a heptamethine cyanine dye. IR-783 induces Mitochondrial membrane potential loss, ATP depletion, mitochondrial permeability transition pore opening, Cytochrome c release and Apoptosis in breast cancer cells. IR-783 promotes the translocation of Drp1 from the cytosol to mitochondria. IR-783 increases the expression of mitochondrial fission proteins such as MFF and Fission-1. IR-783 possesses imaging, cancer-targeting and anticancer properties. IR-783 exerts anticancer effects against breast cancer. IR-783 can be used in breast cancer-related research^[1]. In Vitro:IR-783 (20-100 μM; 24 h for membrane potential assays) induces intracellular ATP depletion and loss of mitochondrial membrane potential in breast cancer MDA-MB-231 cells^[1].
IR-783 (5-120 μM; 6-72 h) selectively inhibits the viability of breast cancer MDA-MB-231 cells in a dose- and time-dependent manner, but exerts no effect on normal hepatocyte LO₂ cells^[1].
IR-783 (20-100 μM; 24 h) induces apoptosis in breast cancer MDA-MB-231 cells in a dose-dependent manner^[1]. In Vivo:IR-783 (20 mg/kg; i.v.; daily; 4 weeks) significantly inhibits MDA-MB-231 xenograft tumour growth (P < .05) via induction of mitochondrial translocation of Drp1 and tumour cell apoptosis, with low observed liver and kidney toxicity^[1].