(3R,5R)-Rosuvastatin
CAS No. : 1094100-06-7
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| Cat. No. : | HY-17504C |
| M.Wt: | 481.54 |
| Formula: | C22H28FN3O6S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM[2]. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[3]. IC50 & Target: IC50: 11 nM (HMG-CoA)[1] and 195 nM (hERG)[2]
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