CAS No. : 1094100-06-7

(Synonyms: (3r,5r,e)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid)

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Cat. No. : HY-17504C
M.Wt: 481.54
Formula: C22H28FN3O6S
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 1094100-06-7 :

(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM[2]. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[3]. IC50 & Target: IC50: 11 nM (HMG-CoA)[1] and 195 nM (hERG)[2]

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