DMT1 blocker 2
CAS No. : 1062648-63-8
| Size | Price | Stock |
|---|---|---|
| 10mg | $300 | In-stock |
| 25mg | $544 | In-stock |
| 50mg | $816 | In-stock |
| 100mg | $1225 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-126302 |
| M.Wt: | 263.29 |
| Formula: | C16H13N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo[1].
IC50 & Target: IC50: 0.83 μM (divalent metal transporter 1)[1]
In Vitro: DMT1 blocker 2 (Compound 12f) (10 μM; 24 h) has no cytotoxic to HepG2 cells[1].
DMT1 blocker 2 (10 μM) inhibits 44% of CYP3A4 activity[1].
In Vivo: DMT1 blocker 2 (50 mg/kg; p.o.) blocks iron uptake by enterocytes in an acute rat model of iron hyperabsorption[1].
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