CAY10603


CAS No. : 1045792-66-2

(Synonyms: BML-281)

1045792-66-2
Price and Availability of CAS No. : 1045792-66-2
Size Price Stock
1mg $72 In-stock
5mg $132 In-stock
10mg $216 In-stock
25mg $420 In-stock
50mg $660 In-stock
100mg $1020 In-stock
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Cat. No. : HY-18613
M.Wt: 446.50
Formula: C22H30N4O6
Purity: >98 %
Solubility: DMSO : ≥ 50 mg/mL (111.98 mM)
Introduction of 1045792-66-2 :

CAY10603 (BML-281) is a potent and selective HDAC6 inhibitor, with an IC50 of 2 pM; CAY10603 (BML-281) also inhibits HDAC1, HDAC2, HDAC3, HDAC8, HDAC10, with IC50s of 271, 252, 0.42, 6851, 90.7 nM. IC50 & Target: IC50: 2 pM (HDAC6), 0.42 nM (HDAC3), 90.7 nM (HDAC10), 252 nM (HDAC2), 271 nM (HDAC1), 6851 nM (HDAC8)[1] In Vitro: CAY10603 (Compound 7) shows potent inhibitory activities against pancreatic cancer cell lines, with IC50s of 1, 0.3, 0.1, 0.1, 0.6, <1, 0.5 μM for BxPC-3, HupT3, Mia Paca-2, Panc 04.03, SU.86.86, HMEC, HPDE6c7, respectively. CAY10603 (100 nM, 200-300 nM) is active against both the Mia Paca-2 and Panc04.03 cell lines[1]. CAY10603 inhibits HDAC6 deacetylase activity, and supresses the proliferation of lung adenocarcinoma cells. CAY10603 also induces apoptosis of lung adenocarcinoma cells. Furthermore, CAY10603 synergizes with gefitinib to induce apoptosis in lung adenocarcinoma cell lines, partly through the destabilization of EGFR and inactivation of the EGFR pathway[2].

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