Flumatinib


CAS No. : 895519-90-1

(Synonyms: HHGV678)

895519-90-1
Price and Availability of CAS No. : 895519-90-1
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5mg $84 In-stock
10mg $108 In-stock
50mg $228 In-stock
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Cat. No. : HY-13904
M.Wt: 562.59
Formula: C29H29F3N8O
Purity: >98 %
Solubility: DMSO : 100 mg/mL (177.75 mM; Need ultrasonic)
Introduction of 895519-90-1 :

Flumatinib (HHGV678) is an orally available, selective inhibitor of Bcr-Abl. Flumatinib inhibits c-Abl, PDGFRβ and c-Kit with IC50s of 1.2 nM, 307.6 nM and 665.5 nM, respectively[1]. IC50 & Target: IC50 Value: 1.2 nM (c-Abl); 307.6 nM(PDGFRβ); 2662 nM (c-Kit)[1]. In Vitro: Flumatinib (HH-GV-678) can predominantly inhibit the autophosphorylation of Bcr-Abl in K562 cell. In higher concentration, Flumatinib can inhibit the phosphorylation of c-Kit in Mo7e cell and the phosphorylation of PDGFR in Swiss3T3 cell, however, Flumatinib has no or little effect on other tyrosine kinase including EGFR, KDR, c-Src and HER2 [1]. Flumatinib (HHGV678) effectively overcame the drug resistance of certain KIT mutants with activation loop mutations (i.e., D820G, N822K, Y823D, and A829P) [2].

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