Size | Price | Stock |
---|---|---|
5mg | $50 | In-stock |
10mg | $70 | In-stock |
25mg | $140 | In-stock |
50mg | $220 | In-stock |
100mg | $350 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
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Cat. No. : | HY-N2149 |
M.Wt: | 415.65 |
Formula: | C27H45NO2 |
Purity: | >98 % |
Solubility: | 0.1 M HCL : < 1 mg/mL (insoluble); DMSO : 16.67 mg/mL (40.11 mM; ultrasonic and warming and heat to 60°C) |
Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling[1]. Tomatidine activates autophagy either in mammal cells or C elegans[2].
IC50 & Target: NF-κB[1]
JNK[1]
In Vitro: Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity[1].
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