CAS No. : 618385-01-6

(Synonyms: SCH 530348)

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Cat. No. : HY-10119
M.Wt: 492.58
Formula: C29H33FN2O4
Purity: >98 %
Solubility: DMSO : ≥ 150 mg/mL (304.52 mM)
Introduction of 618385-01-6 :

Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner[1]. IC50 & Target: Ki: 8.1 nM (PAR-1)[1] In Vitro: Vorapaxar (SCH 530348) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar (SCH 530348) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM[1].

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