FCCP


CAS No. : 370-86-5

(Synonyms: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone)

370-86-5
Price and Availability of CAS No. : 370-86-5
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50mg $228 In-stock
100mg $384 In-stock
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Cat. No. : HY-100410
M.Wt: 254.17
Formula: C10H5F3N4O
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL (393.44 mM); Ethanol : ≥ 33.3 mg/mL (131.01 mM)
Introduction of 370-86-5 :

FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation[1]. In Vitro: FCCP (5 μM) results in a concentration-dependent decrease in Aβ and APPsβ production in K695sw cells. FCCP inhibits processing of wild-type APP. FCCP does not alter cellular ATP levels at any of the concentrations measured. The effects of FCCP on APP catabolism are independent of secondary effects on oxidative phosphorylation or the result of reduced cell viability in K695sw cells. FCCP (5 μM or 500 nM), baf A1, and NH4Cl induce changes in Tf-Tx and Tf-F cellular fluorescence in K695 cells[1]. FCCP (200 nM) protects and enhances the follicle integrity in cat ovarian tissue during short-term in vitro culture. But FCCP does not appear to exert a beneficial or detrimental effect during ovarian tissue cryopreservation[2].

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