Size | Price | Stock |
---|---|---|
5mg | $60 | In-stock |
10mg | $95 | In-stock |
25mg | $190 | In-stock |
50mg | $310 | In-stock |
100mg | $490 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
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Cat. No. : | HY-10593 |
M.Wt: | 362.42 |
Formula: | C21H22N4O2 |
Purity: | >98 % |
Solubility: | DMSO : ≥ 33 mg/mL (91.05 mM) |
IQ 1 is a Wnt/β-catenin/CBP signalling sustainer. IQ 1 maintains long-term expansion of Wnt/β-catenin-driven mouse embryonic stem cells (ESCs) and prevents spontaneous differentiation by enhancing β-catenin/CBP-mediated transcription and preventing conversion to β-catenin/p300-mediated transcription. IQ-1 regulates Wnt signalling by interacting with PR72/130. IQ 1 can be used in study of ESCs expansion[1].
In Vitro:IQ-1 (1.10, 3.48, 11.04 mM; 7 days) maintains the undifferentiated state of ESCs[1].
IQ-1 (0.28, 1.10, 2.76, 11.04 mM; 21 h) maintains murine ESC self-renewal independently of LIF[1].
IQ-1 Binds the PR72/130 Subunit of the Serine/Threonine Phosphatase PP2A in P19 cells[1].
IQ-1 (10 µM; 24 h) modulates Wnt signaling via interaction with PR72/130 in P19 cells[1].
IQ-1 (10 µM; 24 h) indirectly decreases the phosphorylation of p300 Ser-89 and Thereby the β-Catenin/p300 interaction[1].
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