IQ 1

CAS No. : 331001-62-8

Price and Availability of CAS No. : 331001-62-8
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5mg $72 In-stock
10mg $96 In-stock
25mg $216 In-stock
50mg $312 In-stock
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Cat. No. : HY-10593
M.Wt: 362.42
Formula: C21H22N4O2
Purity: >98 %
Solubility: DMSO : ≥ 33 mg/mL (91.05 mM)
Introduction of 331001-62-8 :

IQ 1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on. IQ 1 maintains the pluripotency of murine ESCs in long-term culture in a Wnt-dependent manner. IQ 1 decreased Wnt-stimulated phosphorylation of p300 at Ser-89.IQ-1 binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.The binding of IQ 1 to PR72/130 leads to decreased phosphorylation of the coactivator protein p300 at Ser-89. IQ 1 thereby diminishes the β-catenin/p300 interaction and prevents β-catenin coactivator switching from CBP to p300.

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