IQ 1


CAS No. : 331001-62-8

331001-62-8
Price and Availability of CAS No. : 331001-62-8
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5mg $60 In-stock
10mg $95 In-stock
25mg $190 In-stock
50mg $310 In-stock
100mg $490 In-stock
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Cat. No. : HY-10593
M.Wt: 362.42
Formula: C21H22N4O2
Purity: >98 %
Solubility: DMSO : ≥ 33 mg/mL (91.05 mM)
Introduction of 331001-62-8 :

IQ 1 is a Wnt/β-catenin/CBP signalling sustainer. IQ 1 maintains long-term expansion of Wnt/β-catenin-driven mouse embryonic stem cells (ESCs) and prevents spontaneous differentiation by enhancing β-catenin/CBP-mediated transcription and preventing conversion to β-catenin/p300-mediated transcription. IQ-1 regulates Wnt signalling by interacting with PR72/130. IQ 1 can be used in study of ESCs expansion[1]. In Vitro:IQ-1 (1.10, 3.48, 11.04 mM; 7 days) maintains the undifferentiated state of ESCs[1].
IQ-1 (0.28, 1.10, 2.76, 11.04 mM; 21 h) maintains murine ESC self-renewal independently of LIF[1].
IQ-1 Binds the PR72/130 Subunit of the Serine/Threonine Phosphatase PP2A in P19 cells[1].
IQ-1 (10 µM; 24 h) modulates Wnt signaling via interaction with PR72/130 in P19 cells[1].
IQ-1 (10 µM; 24 h) indirectly decreases the phosphorylation of p300 Ser-89 and Thereby the β-Catenin/p300 interaction[1].

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