D-Serine
CAS No. : 312-84-5
(Synonyms: (R)-Serine)
| Size | Price | Stock |
|---|---|---|
| 1000g | $67 | In-stock |
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| Cat. No. : | HY-100808 |
| M.Wt: | 105.09 |
| Formula: | C3H7NO3 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 50 mg/mL (475.78 mM) |
D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2]. In Vitro: (R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR[3]. In Vivo: (R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain[4].
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