CAS No. : 312-84-5

(Synonyms: (R)-Serine)

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Cat. No. : HY-100808
M.Wt: 105.09
Formula: C3H7NO3
Purity: >98 %
Solubility: H2O : ≥ 50 mg/mL (475.78 mM)
Introduction of 312-84-5 :

D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2]. In Vitro: (R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR[3]. In Vivo: (R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain[4].

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