Size | Price | Stock |
---|---|---|
1mg | $140 | In-stock |
5mg | $420 | In-stock |
10mg | $620 | In-stock |
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100 mg | Get quote | |
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Cat. No. : | HY-100718 |
M.Wt: | 324.38 |
Formula: | C18H20N4O2 |
Purity: | >98 % |
Solubility: | 10 mM in DMSO |
SCH00013 is a cardiotonic agent that primarily acts via an increase in myofibrillar Ca++ sensitivity, have a significant Ca(2+)sensitizing effect at pH 7.2 to 7.4. In vitro: SCH00013 at 10-4 M increased the systolic cell shortening by 52% above the base-line value in association with an insignificant increase in the systolic fluorescence ratio by 15% above the control. [1] In vivo: The positive inotropic effects of 10 4 M SCH00013 on the dog and rabbit were 38% and 29% of the maximal response to isoproterenol. [1] CH00013 elicited a positive inotropic effect at more than 0.3 and 1 mg/kg, i.v. in normal and heart failure dogs. [2] SCH00013 elicits a positive inotropic effect mainly through an increase in myofilament Ca2+ sensitivity without increasing the heart rate. [3]
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