CAS No. : 1627696-51-8

Price and Availability of CAS No. : 1627696-51-8
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5mg $132 In-stock
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Cat. No. : HY-100023
M.Wt: 309.30
Formula: C16H12FN5O
Purity: >98 %
Solubility: DMSO : ≥ 30 mg/mL (96.99 mM)
Introduction of 1627696-51-8 :

LY3177833 (Example 4) is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively. LY3177833 is a senescence inducer[1][2]. IC50 & Target:IC50: 3.3 nM (CDC7), 290 nM (pMCM2)[1] In Vitro:LY3177833 (10 μM; 4 days) increases SA-β-gal content in Hep3B cells[2]. In Vivo:LY3177833 (Example 4; 10.4-31.2 mg/kg; oral gavage; twice a day; for 2 weeks; female athymic Balb/c nude mice with SW620 cells) treatment causes significant tumor regression in a dose-dependent manner. Also, no significant tumor growth is observed for 2 weeks after dosing cessation[1].

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