Abrocitinib
CAS No. : 1622902-68-4
(Synonyms: PF-04965842)
| Size | Price | Stock |
|---|---|---|
| 5mg | $231 | In-stock |
| 10mg | $407 | In-stock |
| 25mg | $735 | In-stock |
| 50mg | $1175 | In-stock |
| 100mg | $1880 | In-stock |
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| Cat. No. : | HY-107429 |
| M.Wt: | 323.41 |
| Formula: | C14H21N5O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (386.51 mM; Need ultrasonic) |
Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease[1]. IC50 & Target: IC50: 29 (JAK1), 803 nM (JAK2)[1] In Vitro: Abrocitinib (Compound 25) inhibits IFNα-stimulated phosphorylation of STAT3, IFN-stimulated phosphorylation of STAT1 in human whole blood (HWB), as well as pSTAT5 in CD34+ spiked into HWB (JAK2), with IC50s of 189, 163 nM, 7.178 μM, respectively[1]. In Vivo: Abrocitinib (Compound 25; 5, 15, 50 mg/kg, p.o., daily for 7 days) significantly reduces paw swelling in rat adjuvant-induced arthritis model[1].
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