Size | Price | Stock |
---|---|---|
5mg | $70 | In-stock |
10mg | $120 | In-stock |
25mg | $240 | In-stock |
50mg | $390 | In-stock |
100mg | $630 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
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Cat. No. : | HY-19737A |
M.Wt: | 455.22 |
Formula: | C20H22BrCl2N3 |
Purity: | >98 % |
Solubility: | H2O : 14.29 mg/mL (31.39 mM; Need ultrasonic) |
DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC50 of 27 nM. IC50 & Target: IC50: 27 nM (PPARβ/δ)[1] In Vitro: DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC50 of 27 nM. DG172 enhances transcriptional corepressor recruitment, and down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC50, 9.5 nM)[1]. DG172 (1 µM) promotes the differentiation of dendritic cells (DCs) from GM-CSF-induced mouse bone marrow cells (BMCs) and reduces Ly6b+/Gr1+ granulocytic cells. DG172 has effects on the transcriptome of GM-CSF differentiated BMCs from WT and Ppard null mice, and acts at a specific stage of GM-CSF-induced differentiation[2]. DG172 (0.1, 1.0 µM) dose-dependently promotes proliferation of TM4 cells. DG172 reduces expression of claudin-11 in TM4 cells[3].
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