DG172 (dihydrochloride)


CAS No. : 1361504-77-9

1361504-77-9
Price and Availability of CAS No. : 1361504-77-9
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10mg $120 In-stock
50mg $468 In-stock
100mg $804 In-stock
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Cat. No. : HY-19737A
M.Wt: 455.22
Formula: C20H22BrCl2N3
Purity: >98 %
Solubility: H2O : 14.29 mg/mL (31.39 mM; Need ultrasonic)
Introduction of 1361504-77-9 :

DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC50 of 27 nM. IC50 & Target: IC50: 27 nM (PPARβ/δ)[1] In Vitro: DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC50 of 27 nM. DG172 enhances transcriptional corepressor recruitment, and down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC50, 9.5 nM)[1]. DG172 (1 µM) promotes the differentiation of dendritic cells (DCs) from GM-CSF-induced mouse bone marrow cells (BMCs) and reduces Ly6b+/Gr1+ granulocytic cells. DG172 has effects on the transcriptome of GM-CSF differentiated BMCs from WT and Ppard null mice, and acts at a specific stage of GM-CSF-induced differentiation[2]. DG172 (0.1, 1.0 µM) dose-dependently promotes proliferation of TM4 cells. DG172 reduces expression of claudin-11 in TM4 cells[3].

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