ML-210
CAS No. : 1360705-96-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $99 | In-stock |
| 10mg | $176 | In-stock |
| 50mg | $528 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-100003 |
| M.Wt: | 475.32 |
| Formula: | C22H20Cl2N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (52.60 mM; Need ultrasonic) |
ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity[1][2].
IC50 & Target: Glutathione Peroxidase 4 (GPX4)[1]
In Vitro: ML-210 exhibits cell-killing activity across a panel of 821 cancer cell lines (WM88, LOX-IMVI, CJM, U257, CAKI2, A498, HT1080, MC38, PANC02). ML-210 is a prodrug that requires cellular activation to bind GPX4[1].
ML-210 has IC50s of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively[2].
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