CAS No. : 1360705-96-9

Price and Availability of CAS No. : 1360705-96-9
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Cat. No. : HY-100003
M.Wt: 475.32
Formula: C22H20Cl2N4O4
Purity: >98 %
Solubility: DMSO : 25 mg/mL (52.60 mM; Need ultrasonic)
Introduction of 1360705-96-9 :

ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity[1][2]. IC50 & Target: Glutathione Peroxidase 4 (GPX4)[1] In Vitro: ML-210 exhibits cell-killing activity across a panel of 821 cancer cell lines (WM88, LOX-IMVI, CJM, U257, CAKI2, A498, HT1080, MC38, PANC02). ML-210 is a prodrug that requires cellular activation to bind GPX4[1].
ML-210 has IC50s of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively[2].

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