P7C3-A20
CAS No. : 1235481-90-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $99 | In-stock |
| 25mg | $125 | In-stock |
| 50mg | $209 | In-stock |
| 100mg | $319 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15978 |
| M.Wt: | 506.21 |
| Formula: | C22H19Br2FN2O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL (197.55 mM) |
P7C3-A20 is a derivative of P7C3 with potent proneurogenic and neuroprotective activity. P7C3-A20 exerts an antidepressant-like effect. P7C3-A20 can cross the blood-brain barrier and therefore has the potential for brain injury treatment[1][2][3].
In Vitro: P7C3-A20 (10-100 μM; 8 hours; PC12 cells) treatment alleviates oxygen-glucose deprivation (OGD)-induced cytotoxicity in PC12 cells[1].
P7C3-A20 (40-100 μM; 8 hours; PC12 cells) treatment alleviates OGD-induced apoptosis in PC12 cells[1].
In Vivo: P7C3-A20 (5-10 mg/kg; intraperitoneal injection; daily; for 7 days; Sprague-Dawley rats) treatment reduces infarct volume; reverses cell loss in the cortex and hippocampus and improves motor function without causing neurotoxicity in HI model rats. P7C3-A20 prevents HI-induced neuronal injury via activation of the PI3K/AKT/GSK3β signaling pathway[1].
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