CAS No. : 310456-65-6

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Cat. No. : HY-100431
M.Wt: 353.41
Formula: C15H15NO5S2
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL (282.96 mM)
Introduction of 310456-65-6 :

IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth[1]. IC50 & Target: IC50: 26 nM (Notch)[1] In Vivo: IMR-1 (i.p.; 15mg/kg; for 28 days) inhibits Notch-dependent tumor growth in patient-derived xenograft models[1].

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