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Nelfinavir (Mesylate)


CAS No. : 159989-65-8

(Synonyms: AG 1343 Mesylate)

159989-65-8
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Cat. No. : HY-15287A
M.Wt: 663.89
Formula: C33H49N3O7S2
Purity: >98 %
Solubility: DMSO : 100 mg/mL (150.63 mM; Need ultrasonic)
Introduction of 159989-65-8 :

Nelfinavir Mesylate (AG 1343 Mesylate) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir Mesylate (AG 1343 Mesylate) is a broad-spectrum, anticancer agent[1][2][3]. IC50 & Target: Ki: 2 nM (HIV-1 protease)[2] In Vitro: Nelfinavir (AG1341) Mesylate (1-10 μM; 48 hours) inhibits the proliferation of multiple myeloma cells[4].
Nelfinavir Mesylate inhibits 26S chymotrypsin-like proteasome activity, impairs proliferation and triggers apoptosis of the myeloma cell lines and fresh plasma cells[4].
Nelfinavir Mesylate (1-10 μM; 17 hours) induces apoptosis of multiple myeloma cell lines[4].
Nelfinavir Mesylate (5 μM; 0-24 hours) decreases the phosphorylation of AKT[4].
Nelfinavir Mesylate activates the cleavage of caspase-3, decreases the phosphorylation of AKT, STAT-3, ERK1/2, and activates the pro-apoptotic pathway of the unfolded protein response system[4].
Nelfinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 35.93 μM[5]. In Vivo: Nelfinavir Mesylate (75 mg/kg; i.p.; 5 days a week for 21 days) decreases multiple myeloma cell growth in NOD/SCID mice[4].

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