YYA-021


CAS No. : 144217-65-2

144217-65-2
Price and Availability of CAS No. : 144217-65-2
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5mg $75 In-stock
10mg $90 In-stock
25mg $190 In-stock
50mg $300 In-stock
100mg $340 In-stock
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Cat. No. : HY-100039
M.Wt: 317.43
Formula: C18H27N3O2
Purity: >98 %
Solubility: DMSO : 50 mg/mL (157.52 mM; Need ultrasonic)
Introduction of 144217-65-2 :

YYA-021 is a small-molecule CD4 mimic that inhibits HIV entry, with high anti-HIV activity and low cytotoxicity. IC50 value: 8.4 μM Target: HIV IC50 (=8.4 μM) value of YYA-021 is determined by a single round assay using cYTA48P virus and TZM-bl cells. YYA-021 is broadly distributed in tissues, probably as a result of its hydrophobicity. The plasma concentrations of YYA-021 in both species remained at micromolar levels for several hours post-injection. [1] YYA-021 also enhances the neutralizing activity of KD-247 against simian-human immunodeficiency virus (SHIV)-KS661 strain via highly synergistic interactions. YYA-021 might have promise as a lead compound for the intravenous administration in a cocktail therapy with anti-gp120 monoclonal antibodies such as KD-247 and with co-receptor antagonists such as T140. [2]

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