RG14620
CAS No. : 136831-49-7
(Synonyms: Tyrphostin RG14620)
| Size | Price | Stock |
|---|---|---|
| 5mg | $61 | In-stock |
| 10mg | $88 | In-stock |
| 50mg | $330 | In-stock |
| 100mg | $550 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101426 |
| M.Wt: | 275.13 |
| Formula: | C14H8Cl2N2 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (121.14 mM; Need ultrasonic) |
RG14620 is an EGFR inhibitor with an IC50 of 3 μM. IC50 & Target: IC50: 3 μM (EGFR)[1] In Vitro: RG14620 inhibits colony formation (IC50=3 μM) and DNA synthesis (IC50=1 μM) by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. RG14620 also suppresses colony formation(IC50=4 μM) and DNA synthesis (IC50=1.25 μM) by EGF-stimulated MH-85 cells in a dose-dependent manner. The growth-inhibitory effect of RG14620 irreversible[2]. In Vivo: RG14620, at a dose of 200 g/mouse/day inhibits H-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals[2].
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