CAS No. : 136831-49-7

(Synonyms: Tyrphostin RG14620)

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Cat. No. : HY-101426
M.Wt: 275.13
Formula: C14H8Cl2N2
Purity: >98 %
Solubility: DMSO : 33.33 mg/mL (121.14 mM; Need ultrasonic)
Introduction of 136831-49-7 :

RG14620 is an EGFR inhibitor with an IC50 of 3 μM. IC50 & Target: IC50: 3 μM (EGFR)[1] In Vitro: RG14620 inhibits colony formation (IC50=3 μM) and DNA synthesis (IC50=1 μM) by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. RG14620 also suppresses colony formation(IC50=4 μM) and DNA synthesis (IC50=1.25 μM) by EGF-stimulated MH-85 cells in a dose-dependent manner. The growth-inhibitory effect of RG14620 irreversible[2]. In Vivo: RG14620, at a dose of 200 g/mouse/day inhibits H-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals[2].

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