A-1155463


CAS No. : 1235034-55-5

1235034-55-5
Price and Availability of CAS No. : 1235034-55-5
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5mg $168 In-stock
10mg $252 In-stock
50mg $840 In-stock
100mg $1380 In-stock
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Cat. No. : HY-19725
M.Wt: 669.79
Formula: C35H32FN5O4S2
Purity: >98 %
Solubility: DMSO : 50 mg/mL (74.65 mM; Need ultrasonic)
Introduction of 1235034-55-5 :

A-1155463 is a highly potent and selective BCL-XL inhibitor with an EC50 of 70 nM in Molt-4 cell. IC50 & Target: EC50: 70 nM (BCL-XL, Molt-4 cell)[1] In Vitro: A-1155463 shows picomolar binding affinity to BCL-XL (Ki<0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki= 80 nM) and related proteins BCL-W (Ki= 19 nM) and MCL-1 (Ki> 440 nM) [2]. A-1155463 demonstrates strong growth inhibition of over half of the colorectal cell lines as defined by EC50 values ≤0.5 μM in the presence of 10 % FBS[3]. In Vivo: A-1155463 caused a mechanism-based and reversible thrombocytopenia in mice and inhibited H146 small cell lung cancer xenograft tumor growth in vivo following multiple doses[2].

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